People

Gador Canton

Gador Canton Research Assistant Professor

  gcanton@uw.edu
  206-897-1315
  MEB 261
  South Lake Union North Building, #133B
  Vascular Imaging Laboratory

Education

  • Ph.D. in Mechanical Engineering, University of California, San Diego, 2004
  • M.S. in Mechanical Engineering, University of California, San Diego, 2002
  • B.S. in Chemical Engineering, Universidad Complutense, Madrid (Spain), 1998

Biography

Professor Canton joined Mechanical Engineering after working in the Radiology Department at the Vascular Imaging Laboratory (VIL). She obtained a Ph.D. in Mechanical Engineering at UCSD where she was exposed to a multidisciplinary environment, working with both neurosurgeons, and bio- and mechanical engineers, who mentored her through her Ph.D. studies in understanding the hemodynamics of cerebral aneurysms. She collaborated with different biomedical companies, such as MicroVention and Boston Scientific, in testing the effectiveness of the treatment techniques that they were developing for these aneurysms. The relevance of this work is reflected by the frequency that her manuscripts have been cited.

Her Ph.D. training in analyzing biomedical problems from an engineering perspective and her interaction with neurosurgeons allowed her to successfully move from an engineering oriented environment to a more clinical one when she started working at the VIL. While at VIL, she got familiarized with the principles of magnetic resonance imaging (MRI) and used them to measure the compliance of carotid atherosclerotic plaques. She also extracted the velocity data provided by phace-contrast MRI to define the boundary conditions of the computational models that she developed to analyze the hemodynamical forces involved in the progression of carotid atherosclerosis. She was trained by VIL's expert radiologists to interpret the MR images of this disease, which allows her to explore the hypothesis that the evolution of this disease can be predicted based on mechanical parameters such as vessel wall distensibility and fluid wall shear stresses.

Research

Atherosclerotic carotid hemodynamic involvement in mechanisms underlying stroke (PI)
The fundamental question that we want to explore is whether we can identify and understand the mechanisms leading to stroke triggered by carotid atherosclerosis' hemodynamics. Although it is widely accepted that hemodynamic forces play an important role in the initiation of atherosclerotic disease, insight is still lacking regarding their role in lesion progression and outcome.
Intracranial vessel wall characterization in intracranial aneurysms and its relationship with intra-aneurysmal hemodynamics
We aim to understand the pathophysiology of intracranial aneurysms by combining magnetic resonance imaging of the aneurysm vessel wall and histological findings with the distribution of hemodynamic forces along the aneurismal wall.

Select publications

  1. Chen Y, Canton G, Kerwin WS, Chiu B. Modeling hemodynamic forces in carotid artery based on local geometric features. Medical & Biological Engineering & Computing. 2016; 54(9):1437-52.
  2. Sun J, Canton G, Balu N, Hippe DS, Xu D, Liu J, Hatsukami TS, Yuan C. Blood Pressure Is a Major Modifiable Risk Factor Implicated in Pathogenesis of Intraplaque Hemorrhage: An In Vivo Magnetic Resonance Imaging Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36(4):743-9.
  3. Xu C, Yuan C, Stutzman E, Canton G, Comess KA, Beach KW. Quest for the Vulnerable Atheroma: Carotid Stenosis and Diametric Strain--A Feasibility Study. Ultrasound in Medicine & Biology. 2016; 42(3):699-716.
  4. O'Brien KD, Hippe DS, Chen H, Neradilek MB, Probstfield JL, Peck S, Isquith DA, Canton G, Yuan C, Polissar NL, Zhao XQ, Kerwin WS. Longer duration of statin therapy is associated with decreased carotid plaque vascularity by magnetic resonance imaging. Atherosclerosis. 2016; 245:74-81.
  5. Helck A, Bianda N, Canton G, Yuan C, Hippe DS, Reiser MF, Gallino A, Wyttenbach R, Saam T. Intra-individual comparison of carotid and femoral atherosclerotic plaque features with in vivo MR plaque imaging. The International Journal of Cardiovascular Imaging. 2015; 31(8):1611-8.
  6. Sun J, Zhao XQ, Balu N, Hippe DS, Hatsukami TS, Isquith DA, Yamada K, Neradilek MB, Cantón G, Xue Y, Fleg JL, Desvigne-Nickens P, Klimas MT, Padley RJ, Vassileva MT, Wyman BT, Yuan C. Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study. The International Journal of Cardiovascular Imaging. 2015; 31(1):95-103.
  7. Tang D, Kamm RD, Yang C, Zheng J, Canton G, Bach R, Huang X, Hatsukami TS, Zhu J, Ma G, Maehara A, Mintz GS, Yuan C. Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: data, modeling, validation, uncertainty and predictions. Journal of Niomechanics. 2014; 47(4):834-46.
  8. Tang D, Yang C, Canton G, Wu Z, Hatsukami T, Yuan C. Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models. BioMedical Engineering Online. 2013; 12:105.
  9. Canton G, Chiu B, Chen H, Chen Y, Hatsukami TS, Kerwin WS, Yuan C. A framework for the co-registration of hemodynamic forces and atherosclerotic plaque components. Physiological Measurement. 2013; 34(9):977-90.
  10. Huang XY, Yang C, Cantón G, Ferguson M, Yuan C, Tang DL. Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models. Journal of Biomechanical Engineering 134(12):121004, 2012.
  11. Cantón G, Hippe DS, Sun J, Kerwin WS, Tang D, Yuan C. Characterization of distensibility, plaque burden and composition of the atherosclerotic carotid artery using magnetic resonance imaging Medical Physics 39(10):6247- 6254, 2012.
  12. Liu H., Cantón G, Yuan C, Yang C, Billiar K, Teng Z, Hoffman AH, Tang D. Using in vivo cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictions. Journal of Biomechanical Engineering 134(1):011008, 2012.
  13. Yang C, Cantón G, Yuan C, Ferguson M, Hatsukami TS, Tang D. Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress. BioMedical Engineering OnLine 10:61, 2011.
  14. Huang X, Teng Z, Cantón G., Ferguson M, Yuan C, Tang D. Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3d fluid-structure interaction study. BioMedical Engineering OnLine 9:86, 2010.
  15. Wang J, Balu N, Cantón G, Yuan C. Imaging biomarkers of cardiovascular disease. Journal of Magnetic Resonance in Medicine 32(3):502-515, 2010.