Nathan Sniadecki - Associate Professor
- Campus Office: MEB 318
- Campus Phone: 206-685-6591
- Lab: Brotman 442, UW Medicine, South Lake Union Campus
- Lab Office Phone: 206-685-2148
- Email: firstname.lastname@example.org
- Website: Cell Biomechanics Lab
- University of Notre Dame (BS, 2000)
- University of Maryland at College Park (MS/PhD, 2003)
- The Johns Hopkins University (Post-Doc Fellow, 2004)
- University of Pennsylvania (Post-Doc Fellow, 2007)
- ME 354: Mechanics of Materials Lab
- ME 356: Machine Design Analysis
- ME 411/511: Biological Frameworks for Engineers
- ME 478: Finite Element Analysis
- ME 495: Capstone Design - Phantom Heart
- ME 599: Analysis and Modeling of Cell Mechanics
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Prof. Nathan Sniadecki's research is in the areas of cell biomechanics, bioMEMs, and bioinstrumentation. Specifically, his lab is developing micro- and nano-scale tools to understand the mechanical properties of cells. His lab uses arrays of flexible microposts to measure the traction forces of cells, computational modeling to examine cell mechanics, and microfluidic devices to investigate mechanotransduction in the cardiovascular system. The long-term goals of his work are to understand the ways in which mechanics plays a role in tissue growth and cardiovascular disease and how cell mechanics can be used to improve human health through better diagnostic systems and improved tissue engineering. Prof. Sniadecki received the NSF CAREER Award in 2009, the DARPA Young Faculty Award in 2011, the Albert Kobayashi Professorship in 2013, and the Lloyd Hamilton Donnell Applied Mechanics Review Paper Award in 2014. Prof. Sniadecki is an associate editor for ASME's Journal of Biomechanical Engineering.
- Kuppusamy, K.T., Jones, D., Sperber, H., Madan, A., Fisher, K., Rodriguez, M.L., Pabon, L. Zhu, W.Z., Tulloch, N., Yang, X., Sniadecki, N.J., Laflamme, M.A., Ruzzo, W.L., Murry, C.E., Ruohola-Baker, H. (2015) Let-7 Family of miRNA Is Required For Maturation and Adult-like Metabolism in Stem Cell-Derived Cardiomyocytes. Proceedings of the National Academy of Sciences – USA. 112(21):E2785-94.
- Rodriguez, M.L., McGarry, P., Sniadecki, N.J. (2013) Review on Cell Mechanics: Experimental and Modeling Approaches, Applied Mechanics Reviews. 65(6), 060801.
- Han, S.J., Ting, L.H., Bielawski, K.S., Rodriguez, M.L., Sniadecki, N.J. (2012) Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship Between Traction Forces and Focal Adhesions. Biophysical Journal. 103(4): 640-8.
- Ting, L.H., Jahn, J.R., Jung, J.I., Shuman, B.R., Feghhi, S., Han, S.J., Rodriguez, M.L. Sniadecki, N.J. (2012) Flow Mechanotransduction Regulates Traction Forces, Intercellular Forces, and Adherens Junctions. American Journal of Physiology – Heart and Circulatory Physiology. 302:H2220-H2229.
- Rodriguez, A.G., Han, S.J., Regnier, M., Sniadecki, N.J. (2011) Substrate Stiffness Increases Twitch Power of Neonatal Cardiomyocytes in Correlation with Changes in Myofibril Structure and Intracellular Calcium. Biophysical Journal. 101(10):2455-2464.
- Liang, X.M, Han, S.J., Reems, J.A., Gao, D., Sniadecki, N.J., (2010) Platelet Retraction Force Measurements Using Flexible Post Force Sensors. Selected for the Cover of Lab on a Chip. 10(8): 991-8.
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