Nathan Sniadecki - Associate Professor
- Phone: 206-685-6591
- Office: MEB 318
- Lab: AERB 317
- Email: firstname.lastname@example.org
- Website: Cell Biomechanics Lab
- University of Notre Dame (BS, 2000)
- University of Maryland at College Park (MS/PhD, 2003)
- The Johns Hopkins University (Post-Doc Fellow, 2004)
- University of Pennsylvania (Post-Doc Fellow, 2007)
- Mechanics, Materials and Manufacturing
- ME354: Mechanics of Materials Lab
- ME411/511: Biological Frameworks for Engineers
- ME478: Finite Element Analysis
- ME495: Capstone Design - Phantom Heart
- ME599: Analysis and Modeling of Cell Mechanics
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Prof. Nathan Sniadecki's research is in the areas of cell biomechanics, bioMEMs, and bioinstrumentation. Specifically, his lab is developing micro- and nano-scale tools to understand the mechanical properties of cells . His lab uses flexible post force sensors to measure cellular contraction forces, computational modeling to examine cell mechanics, and shear flow devices to investigate mechanotransduction in the cardiovascular system. The long-term goals of his work are to understand the ways in which mechanics plays a role in tissue growth and cardiovascular disease and how cell mechanics can be used to improve human health through better diagnostic systems and improved tissue engineering. Prof. Sniadecki received the NSF CAREER Award in 2009 and the DARPA Young Faculty Award in 2011.
- Han, S.J., Ting, L.H., Bielawski, K.S., Rodriguez, M.L., Sniadecki, N.J. (2012) Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship Between Traction Forces and Focal Adhesions. Biophys J. 103(4): 640-8.
- Ting, L.H., Jahn, J.R., Jung, J.I., Shuman, B.R., Feghhi, S., Han, S.J., Rodriguez, M.L. Sniadecki, N.J. (2012) Flow Mechanotransduction Regulates Traction Forces, Intercellular Forces, and Adherens Junctions. American Journal of Physiology – Heart and Circulatory Physiology. 302:H2220-H2229.
- Rodriguez, A.G., Han, S.J., Regnier, M., Sniadecki, N.J. (2011) Substrate Stiffness Increases Twitch Power of Neonatal Cardiomyocytes in Correlation with Changes in Myofibril Structure and Intracellular Calcium. Biophys J. 101(10):2455-2464.
- Liang, X.M, Han, S.J., Reems, J.A., Gao, D., Sniadecki, N.J., (2010) Platelet Retraction Force Measurements Using Flexible Post Force Sensors. Selected for the Cover of Lab on a Chip. 10(8): 991-8.
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