Jonathan T. C. Liu
Bryan T. McMinn Endowed Professorship
- (206) 543-5339
- MEB 207
- Molecular Biophotonics Laboratory
Jonathan Liu was born in Albany, NY and raised in Honolulu, HI, where he
attended the Iolani School. Jonathan received degrees in mechanical
engineering at Princeton and Stanford. He was a postdoctoral fellow in
the department of electrical engineering (Ginzton Labs) and the
Molecular Imaging Program at Stanford, and was later appointed as an
instructor within the Stanford University School of Medicine. Jonathan
spent four years as an assistant professor of biomedical engineering at
the State University of New York (SUNY) at Stony Brook prior to moving
to the department of mechanical engineering at the University of
Washington in 2014.
- Ph.D. in Mechanical Engineering, Stanford University, 2005
- M.S. in Mechanical Engineering, Stanford University, 2000
- BSE in Mechanical Engineering / Engineering Physics, Princeton University, 1999
- Assistant Professor, Biomedical Engineering, Stony Brook University, 2010-2014
- Instructor, Stanford University School of Medicine, 2009-2010
- Postdoc, Stanford University Electrical Engineering and School of Medicine, 2005-2009
Jonathan Liu is director of the Molecular Biophotonics Laboratory,
which is developing optical strategies for biomedical diagnostics and
therapy. These endeavors require multi-disciplinary advances in optical
devices, contrast agents, image processing, and preclinical/clinical
studies. For example, the lab is developing miniature optical-sectioning
microscopy devices and molecularly targeted contrast agents to enable
the early detection of cancer and to guide the surgical resection of
tumors. These technologies have the potential to revolutionize patient
care by providing surgeons with a real-time alternative to invasive
biopsy and histopathology. In addition, the lab is developing spectral
imaging devices in conjunction with biomarker-targeted nanoparticles for
the endoscopic visualization of large panels of disease biomarkers
(molecular phenotyping). Finally, the lab is developing advanced
microscopy techniques to enable slide-free nondestructive molecular 3D
pathology. This has the potential to significantly improve upon current
“gold-standard” diagnostic pathology methods and ultimately to optimize
treatment decisions and patient outcomes.
- Y. Wang, N.P. Reder, S. Kang, A.K. Glaser, Q. Yang, M.A. Wall, S.H. Javid, S.M. Dintzis, and J.T.C. Liu, "Raman-encoded molecular imaging (REMI) with topically applied SERS nanoparticles for intraoperative guidance of lumpectomy," Cancer Research 77, 4506 (2017).
- A.K. Glaser, N.P. Reder, Y. Chen, E.F. McCarty, C. Yin, L. Wei, Y. Wang, L.D. True, and J.T.C. Liu, "Light-sheet microscopy for slide-free nondestructive pathology of large clinical specimens," Nature Biomedical Engineering 1, 0084 (2017).
- Y. Wang, J.D. Doerksen, S. Kang, D. Walsh, Q. Yang, D. Hong, and J.T.C. Liu, "Multiplexed molecular imaging of fresh tissue surfaces enabled by convection-enhanced topical staining with SERS-coded nanoparticles," Small 12, 5612 (2016).
- A. Glaser, Y. Chen, and J.T.C. Liu, "Fractal propagation method enables realistic optical microscopy simulations in biological tissues," Optica 3, 861 (2016).
- C. Yin, A.K. Glaser, S.Y. Leigh, Y. Chen, Linpeng Wei, P.C.S. Pillai, M. Rosenberg, S. Abeytunge, G. Peterson, C. Glazowski, N. Sanai, M.J. Mandella, M. Rajadhyaksha, and J.T.C. Liu, "A miniature in vivo MEMS-based line-scanned dual-axis confocal microscope for point-of-care pathology," Biomed Opt. Exp. 7, 251 (2016).
- Y. Wang, S. Kang, A. Khan, P. Bao, and J.T.C. Liu, "In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles," Biomed. Opt. Exp. 6, 3714 (2015).
- K.M. Tichauer, Y. Wang, Brian W. Pogue, and J.T.C. Liu, "Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling & paired-agent principles from nuclear medicine and optical imaging," Physics in Medicine and Biology 60, R239 (2015).
- C. Zavaleta, E. Garai, J.T.C. Liu, S. Sensarn, M.J. Mandella, D. Van de Sompel, S. Friedland, J. Van Dam, C.H. Contag, and S.S. Gambhir, "A Raman-based endoscopic strategy for multiplexed molecular imaging," Proc. Natl. Acad. Sci. U.S.A. 110, 2288 (2013).
Honors & awards
- Bryan T. McMinn Endowed Professorship in Mechanical Engineering, Univ. of Washington (2016–2019)
- Outstanding Teacher Award, 12/2013, Stony Brook University
- K99/R00 Pathway to Independence Award, 2009–2014, NIH / NIBIB
- Top Oral Presentation Award, 2009, Center for Biomedical Imaging at Stanford (CBIS) symposia
- Canary Foundation / American Cancer Society postdoctoral fellowship award, 2005–2008
- AIAA Wright Brothers Graduate Award, 2003
- NSF Graduate Fellowship Award, 1999–2002
- Tau Beta Pi, Phi Beta Kappa, and Sigma Xi Book Award, 1999, Princeton University
- Sau-Hai Lam *58 Prize as the top graduate in mechanical and aerospace engineering, 1999, Princeton University
Scanning tumors during surgery
A versatile light-sheet microscope, developed by a UW team including ME associate professor Jonathan Liu, can provide...
A fruitful collaboration
Associate professor Jonathan Liu explains how the opportunity to collaborate with the School of Medicine attracted him...
NIH director reports on ME research
Dr. Francis Collins, director of the National Institutes of Health (NIH), reported on Jonathan Liu’s new light-sheet...
Congratulations ME awardees!
Congratulations to the ME faculty, students and staff members who received 2018 College of Engineering Awards: ...